Cancer diagnosis and treatment platform based on manganese-based nanomaterials

Jia Fei; Yanyan Liu; Ya Zeng; Mingqi Yang; Shanshan Chen; Xiaobing Duan; Ligong Lu; Muhe Chen

doi:10.3389/fbioe.2024.1363569

Frontiers in Bioengineering and Biotechnology (Mar 2024)

Cancer diagnosis and treatment platform based on manganese-based nanomaterials

Jia Fei,
Yanyan Liu,
Ya Zeng,
Mingqi Yang,
Shanshan Chen,
Xiaobing Duan,
Ligong Lu,
Muhe Chen

Affiliations

Jia Fei: Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), Zhuhai, China
Yanyan Liu: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China
Ya Zeng: Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), Zhuhai, China
Mingqi Yang: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China
Shanshan Chen: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China
Xiaobing Duan: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China
Ligong Lu: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China
Muhe Chen: Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China

DOI: https://doi.org/10.3389/fbioe.2024.1363569
Journal volume & issue: Vol. 12

Abstract

Read online

Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their multifunctional properties. These nanomaterials have been extensively explored as contrast agents for various imaging technologies such as magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and near-infrared fluorescence imaging (NIR-FL). The use of these nanomaterials has significantly enhanced the contrast for precise tumor detection and localization. Moreover, MnNMs have shown responsiveness to the tumor microenvironment (TME), enabling innovative approaches to cancer treatment. This review provides an overview of the latest developments of MnNMs and their potential applications in tumor diagnosis and therapy. Finally, potential challenges and prospects of MnNMs in clinical applications are discussed. We believe that this review would serve as a valuable resource for guiding further research on the application of manganese nanomaterials in cancer diagnosis and treatment, addressing the current limitations, and proposing future research directions.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

About the journal

Abstract

Keywords