Nature Communications (Feb 2019)

Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay

  • Xiang-Huan Shan,
  • Hong-Xing Zheng,
  • Bo Yang,
  • Lin Tie,
  • Jia-Le Fu,
  • Jian-Ping Qu,
  • Yan-Biao Kang

DOI
https://doi.org/10.1038/s41467-019-08849-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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The synthesis of high value heterocycles from cheap starting materials remains challenging. Here, the authors develop a new strategy to realize practical and modular synthesis of N-H indoles and analogs from toluene and nitrile derivatives using naturally abundant copper salt as catalyst.