ON THE ROLE OF IMMUNOLOGICAL ABNORMALITIES IN THE PATHOGENESIS OF COGNITIVE DYSFUNCTION IN MAJOR DEPRESSIVE DISORDER

Abstract

Major depression correlates to several known immune and endocrine abnormalities (e.g. HPA axis hyperactivity, thymus atrophy, thymic hormone hyposecretion, among others) and is often leading to diminished resistance to infections and oncologic diseases. On the other hand, major depression is one of the leading causes of cognitive decline, and it is well–known fact that functional and social recovery correlates better to cognitive functioning than to general improvement in depressive symptoms. This article thoroughly reviews different correlations between immune functions and cognition, and the existing evidence base for immune correction of cognitive dysfunctions commonly seen in depressions.

Keywords

• депрессивные состояния
• когнитивные нарушения
• иммунологические нарушения
• тимэктомия
• спленэктомия
• тималин
• тактивин
• тимоген
• спленин
• деринат
• прополис
• дибазол
• левамизол