RNP components condense into repressive RNP granules in the aging brain

Kavya Vinayan Pushpalatha; Mathilde Solyga; Akira Nakamura; Florence Besse

doi:10.1038/s41467-022-30066-4

Nature Communications (May 2022)

RNP components condense into repressive RNP granules in the aging brain

Kavya Vinayan Pushpalatha,
Mathilde Solyga,
Akira Nakamura,
Florence Besse

Affiliations

Kavya Vinayan Pushpalatha: Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose
Mathilde Solyga: Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose
Akira Nakamura: Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Florence Besse: Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose

DOI: https://doi.org/10.1038/s41467-022-30066-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Aberrant RNA condensates are a hallmark of age-related neurodegenerative diseases. Here, the authors show that RNA condensation increases in aging Drosophila brains, triggering translation repression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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