Hearts (Jun 2024)
Bicuspid Aortic Valve Disease with Early-Onset Complications: Characteristics and Aortic Outcomes
- Maximilian A. Selbst,
- Colin R. Ward,
- Megan L. Svetgoff,
- Hector I. Michelena,
- Anna Sabate-Rotes,
- Julie De Backer,
- Laura Muiño Mosquera,
- Anji T. Yetman,
- Malenka M. Bissell,
- Maria Grazia Andreassi,
- Ilenia Foffa,
- Dawn S. Hui,
- Anthony Caffarelli,
- Yuli Y. Kim,
- Dongchuan Guo,
- Rodolfo Citro,
- Margot De Marco,
- Justin T. Tretter,
- Shaine A. Morris,
- Kim L. McBride,
- Simon C. Body,
- Siddharth K. Prakash
Affiliations
- Maximilian A. Selbst
- John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- Colin R. Ward
- John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- Megan L. Svetgoff
- John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- Hector I. Michelena
- Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA
- Anna Sabate-Rotes
- Facultad de Medicina, Hospital Vall d’Hebron, Universidad Autònoma Barcelona, 08193 Barcelona, Spain
- Julie De Backer
- Center for Medical Genetics, Ghent University, B-9000 Ghent, Belgium
- Laura Muiño Mosquera
- Center for Medical Genetics, Ghent University, B-9000 Ghent, Belgium
- Anji T. Yetman
- Division of Pediatric Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
- Malenka M. Bissell
- Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK
- Maria Grazia Andreassi
- Consiglio Nazionale delle Richerche (CNR), Instituto di Fisiologia Clinica, 56124 Pisa, Italy
- Ilenia Foffa
- Consiglio Nazionale delle Richerche (CNR), Instituto di Fisiologia Clinica, 56124 Pisa, Italy
- Dawn S. Hui
- Department of Cardiothoracic Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
- Anthony Caffarelli
- Hoag Hospital Newport Beach, Newport Beach, CA 92663, USA
- Yuli Y. Kim
- Division of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
- Dongchuan Guo
- Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- Rodolfo Citro
- Department of Medicine and Health Sciences V. Tiberio, University of Molise, Responsible Research Hospital, 86100 Campobasso, Italy
- Margot De Marco
- Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy
- Justin T. Tretter
- Department of Pediatric Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
- Shaine A. Morris
- Division of Pediatric Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
- Kim L. McBride
- Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
- Simon C. Body
- Department of Anesthesiology, Boston University School of Medicine, Boston, MA 02215, USA
- Siddharth K. Prakash
- Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- DOI
- https://doi.org/10.3390/hearts5030018
- Journal volume & issue
-
Vol. 5,
no. 3
pp. 253 – 258
Abstract
Bicuspid aortic valve (BAV) is the most common congenital heart malformation in adults, but it can also cause childhood-onset complications. The presentation and clinical course of young adults who present due to BAV complications are relatively uncharacterized. In a multicenter study, we found that young people who experience significant complications related to BAV disease before age 30 are distinguished from the majority of BAV cases that manifest after age 50 by a relatively severe clinical course, with higher rates of surgical interventions, more frequent second interventions, and a greater burden of congenital heart malformations. These observations highlight the need for prompt recognition, regular lifelong surveillance, and targeted interventions to address the significant health burdens of patients with early-onset BAV complications.
Keywords
