Chemistry Proceedings (Nov 2023)

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

  • Pradip Debnath

DOI
https://doi.org/10.3390/ecsoc-27-16131
Journal volume & issue
Vol. 14, no. 1
p. 14

Abstract

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Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of substituted spiro-oxindoles. In this paper, preliminary results regarding the synthesis of 3,3′-spiro pentacyclo-oxindole derivatives via the ring-closing metathesis of 3,3-diallyl oxindoles are reported. The ring-closing metathesis reaction proceeded smoothly with Grubb’s catalyst-I (2 mol%) in toluene at room temperature. The desired products, 3,3′-spiro pentacyclo-oxindoles, were obtained in good to excellent yields under standard reaction conditions.

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