Nature Communications (May 2016)
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility
- Meilin Wang,
- Dongying Gu,
- Mulong Du,
- Zhi Xu,
- Suzhan Zhang,
- Lingjun Zhu,
- Jiachun Lu,
- Rui Zhang,
- Jinliang Xing,
- Xiaoping Miao,
- Haiyan Chu,
- Zhibin Hu,
- Lei Yang,
- Cuiju Tang,
- Lei Pan,
- Haina Du,
- Jian Zhao,
- Jiangbo Du,
- Na Tong,
- Jielin Sun,
- Hongbing Shen,
- Jianfeng Xu,
- Zhengdong Zhang,
- Jinfei Chen
Affiliations
- Meilin Wang
- Department of Oncology, Nanjing First Hospital, Nanjing Medical University
- Dongying Gu
- Department of Oncology, Nanjing First Hospital, Nanjing Medical University
- Mulong Du
- Department of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
- Zhi Xu
- Department of Oncology, Nanjing First Hospital, Nanjing Medical University
- Suzhan Zhang
- Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine
- Lingjun Zhu
- Department of Oncology, First Affiliated Hospital of Nanjing Medical University
- Jiachun Lu
- Institute for Chemical Carcinogenesis, State Key Lab of Respiratory Disease, Guangzhou Medical University
- Rui Zhang
- Department of Colorectal Surgery, Liaoning Cancer Hospital and Institute
- Jinliang Xing
- Department of Cell Biology and Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University
- Xiaoping Miao
- Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
- Haiyan Chu
- Department of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
- Zhibin Hu
- Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Lei Yang
- Institute for Chemical Carcinogenesis, State Key Lab of Respiratory Disease, Guangzhou Medical University
- Cuiju Tang
- Department of Oncology, Nanjing First Hospital, Nanjing Medical University
- Lei Pan
- Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine
- Haina Du
- Department of Oncology, First Affiliated Hospital of Nanjing Medical University
- Jian Zhao
- Department of Colorectal Surgery, Liaoning Cancer Hospital and Institute
- Jiangbo Du
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Na Tong
- Department of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
- Jielin Sun
- Program for Personalized Cancer Care, NorthShore University Health System
- Hongbing Shen
- Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Jianfeng Xu
- Program for Personalized Cancer Care, NorthShore University Health System
- Zhengdong Zhang
- Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University
- Jinfei Chen
- Department of Oncology, Nanjing First Hospital, Nanjing Medical University
- DOI
- https://doi.org/10.1038/ncomms11478
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Genome-wide association studies have been performed to identify genetic variants that are associated with susceptibility to colorectal cancer. Here, the authors expand on these studies and identify a variant that regulates the expression of ETV6 and find that over-expression of ETV6 blocks cell proliferation in vitro.
