Nature Communications (Mar 2019)
Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
- Eun-Ju Im,
- Chan-Hyeong Lee,
- Pyong-Gon Moon,
- Gunassekaran Gowri Rangaswamy,
- Byungheon Lee,
- Jae Man Lee,
- Jae-Chul Lee,
- Jun-Goo Jee,
- Jong-Sup Bae,
- Taeg-Kyu Kwon,
- Keon-Wook Kang,
- Myeong-Seon Jeong,
- Joo-Eun Lee,
- Hyun-Suk Jung,
- Hyun-Joo Ro,
- Sangmi Jun,
- Wonku Kang,
- Seung-Yong Seo,
- Young-Eun Cho,
- Byoung-Joon Song,
- Moon-Chang Baek
Affiliations
- Eun-Ju Im
- Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University
- Chan-Hyeong Lee
- Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University
- Pyong-Gon Moon
- Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University
- Gunassekaran Gowri Rangaswamy
- Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University
- Byungheon Lee
- Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University
- Jae Man Lee
- Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University
- Jae-Chul Lee
- Department of Microbiology, School of Medicine, Kyungpook National University
- Jun-Goo Jee
- Research Institute of Pharmaceutical Researches, College of Pharmacy, Kyungpook National University
- Jong-Sup Bae
- Research Institute of Pharmaceutical Researches, College of Pharmacy, Kyungpook National University
- Taeg-Kyu Kwon
- Department of Immunology and School of Medicine, Keimyung University
- Keon-Wook Kang
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Myeong-Seon Jeong
- Chuncheon Center, Korean Basic Science Institute
- Joo-Eun Lee
- Department of Biochemistry, College of Natural Sciences, Kangwon National University
- Hyun-Suk Jung
- Department of Biochemistry, College of Natural Sciences, Kangwon National University
- Hyun-Joo Ro
- Drug & Disease Target Group, Korea Basic Science Institute
- Sangmi Jun
- Drug & Disease Target Group, Korea Basic Science Institute
- Wonku Kang
- College of Pharmacy, Chung-Ang University
- Seung-Yong Seo
- College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University
- Young-Eun Cho
- Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Byoung-Joon Song
- Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Moon-Chang Baek
- Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University
- DOI
- https://doi.org/10.1038/s41467-019-09387-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Extracellular vesicles are released from cells and permit communication between different cell types. Here, the authors identify that the FDA approved antibiotic sulfisoxazole, can block the release of these vesicles in breast cancer cells resulting in reduced cell growth in vitro and in vivo.
