Base-Promoted <i>S<sub>N</sub>Ar</i> Reactions of Fluoro- and Chloroarenes as a Route to <i>N</i>-Aryl Indoles and Carbazoles
Muhammad Asif Iqbal,
Hina Mehmood,
Jiaying Lv,
Ruimao Hua
Affiliations
Muhammad Asif Iqbal
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
Hina Mehmood
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
Jiaying Lv
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
Ruimao Hua
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.
