He jishu (Feb 2022)

Clinical application of brain perfusion SPECT/CT imaging with NeuroGamTM software in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease

  • LEI Zhe,
  • WU Han,
  • OU Yinghui,
  • XU Qian,
  • SHI Xin,
  • SHI Keqing,
  • ZHAO Qianhua,
  • DING Jing,
  • YIN You,
  • WANG Xiuzhe,
  • LIU Xueyuan,
  • LOU Jingjing,
  • LIU Xingdang

DOI
https://doi.org/10.11889/j.0253-3219.2022.hjs.45.020301
Journal volume & issue
Vol. 45, no. 2
pp. 020301 – 020301

Abstract

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BackgroundSubjective cognitive decline (SCD) and mild cognitive impairment (MCI) are a transitional state between normal aging and mild dementia, and most of them have potential Alzheimer's Disease (AD) pathology. Studying the pathophysiological characteristics of SCD and MCI is helpful to the early diagnosis of AD.PurposeThis study aims to investigate the brain perfusion differences among SCD, MCI and AD, and to evaluate the application value of brain perfusion SPECT/CT imaging combined with NeuroGamTM software in these diseases.MethodsFrom July 2020 to April 2021, 15 patients with SCD, 29 patients with MCI and 36 patients with AD were collected from several general hospitals in Shanghai. All subjects underwent neuropsychological test and 99mTc-ECD brain perfusion SPECT/CT imaging. The perfusion levels of Brodmann areas (BA) in the three groups were semi-quantitatively analyzed by NeuroGamTM, and compared with normal database. Student's t-test, one-way analysis of variance and rank sum test were used for the comparison of quantitative variables. Pearson's chi-squared test was used for the comparison of qualitative variables.ResultsThere is no significant difference in BA 4~11, 17~25, 28, 31~32, 36~40 and 44~47 between SCD group and MCI group. The mean perfusion values of BA 8-right(R), 20-left(L), 21R, 23L, 23R, 24L, 31L, 38L, 38R and 45R in SCD group are significantly higher than those in AD group (p<0.016 7). The mean perfusion values of BA 21R, 23R, 23R, 31L and 39L of MCI group are significantly higher than those in AD group (p<0.016 7). Compared with the normal database, SCD group show hypoperfusion in BA 24L, 24R, 28L and 28R whilst MCI group show hypoperfusion in BA 21L, 21R, 23R, 24L, 24R, 25L, 25R, 28L, 28R, 36L, 36R, 38R and 47L, and AD group show hypoperfusion in BA 21L, 21R, 22L, 23L, 23R, 24L, 24R, 25R, 28L, 28R, 32L, 32R, 36L, 36R, 47L.ConclusionsThere are differences in the degree and range of hypoperfusion in SCD, MCI and AD. Brain perfusion SPECT/CT imaging combined with NeuroGamTM software has certain application value in these diseases and can be used as an auxiliary diagnostic tool.

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