The Journal of Headache and Pain (Jun 2020)
The fifth cranial nerve in headaches
- J. C. A. Edvinsson,
- A. Viganò,
- A. Alekseeva,
- E. Alieva,
- R. Arruda,
- C. De Luca,
- N. D’Ettore,
- I. Frattale,
- M. Kurnukhina,
- N. Macerola,
- E. Malenkova,
- M. Maiorova,
- A. Novikova,
- P. Řehulka,
- V. Rapaccini,
- O. Roshchina,
- G. Vanderschueren,
- L. Zvaune,
- A. P. Andreou,
- K. A. Haanes,
- On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)
Affiliations
- J. C. A. Edvinsson
- Department of Clinical Experimental Research, Glostrup Research Institute
- A. Viganò
- IRCCS Fondazione Don Carlo Gnocchi
- A. Alekseeva
- Department of Neurology, First Pavlov State Medical University of St.Petersburg
- E. Alieva
- GBUZ Regional Clinical Hospital № 2
- R. Arruda
- Department of Neuroscience, University of Sao Paulo
- C. De Luca
- Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa
- N. D’Ettore
- Department of Neurology, University of Rome, Tor Vergata
- I. Frattale
- Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila
- M. Kurnukhina
- Department of Neurosurgery, First Pavlov State Medical University of St.Petersburg
- N. Macerola
- Department of Internal Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore
- E. Malenkova
- Pain Department, Petrovsky National Research Centre of Surgery
- M. Maiorova
- Faculty of Medicine, University of Tartu
- A. Novikova
- F.F. Erisman Federal Research Center for Hygiene
- P. Řehulka
- Department of Neurology, St. Anne’s University Hospital and Faculty of Medicine, Masaryk University
- V. Rapaccini
- Child Neurology and Psychiatry Unit, Systems Medicine Department, University Hospital Tor Vergata
- O. Roshchina
- Department of Neurology, First Pavlov State Medical University of St.Petersburg
- G. Vanderschueren
- Department of Neurology, ZNA Middelheim
- L. Zvaune
- Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Riga Stradins University
- A. P. Andreou
- Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- K. A. Haanes
- Department of Clinical Experimental Research, Glostrup Research Institute
- On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)
- DOI
- https://doi.org/10.1186/s10194-020-01134-1
- Journal volume & issue
-
Vol. 21,
no. 1
pp. 1 – 17
Abstract
Abstract The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.
Keywords
