Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

Adriana Arena; Carlo Bisignano; Giovanna Stassi; Angela Filocamo; Giuseppina Mandalari

doi:10.3390/molecules20058816

Molecules (May 2015)

Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

Adriana Arena,
Carlo Bisignano,
Giovanna Stassi,
Angela Filocamo,
Giuseppina Mandalari

Affiliations

Adriana Arena: Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy
Carlo Bisignano: Department of Biological and Environmental Science, University of Messina, Sal. Sperone 31, Messina 98100, Italy
Giovanna Stassi: Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy
Angela Filocamo: Department of Drug Science and Products for Health, Vill. SS. Annunziata, Messina 98100, Italy
Giuseppina Mandalari: Department of Drug Science and Products for Health, Vill. SS. Annunziata, Messina 98100, Italy

DOI: https://doi.org/10.3390/molecules20058816
Journal volume & issue: Vol. 20, no. 5
pp. 8816 – 8822

Abstract

Read online

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords