Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone

Carol Cho; Juwon Jang; Yujin Kang; Hiroki Watanabe; Takayuki Uchihashi; Seung Joong Kim; Koichi Kato; Ja Yil Lee; Ji-Joon Song

doi:10.1038/s41467-019-13743-9

Nature Communications (Dec 2019)

Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone

Carol Cho,
Juwon Jang,
Yujin Kang,
Hiroki Watanabe,
Takayuki Uchihashi,
Seung Joong Kim,
Koichi Kato,
Ja Yil Lee,
Ji-Joon Song

Affiliations

Carol Cho: Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)
Juwon Jang: Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)
Yujin Kang: School of Life Sciences, Ulsan National Institute of Science and Technology
Hiroki Watanabe: Institute for Molecular Science (IMS), National Institutes of Natural Sciences
Takayuki Uchihashi: Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences
Seung Joong Kim: Department of Physics, Korea Advanced Institute of Science and Technology (KAIST)
Koichi Kato: Institute for Molecular Science (IMS), National Institutes of Natural Sciences
Ja Yil Lee: School of Life Sciences, Ulsan National Institute of Science and Technology
Ji-Joon Song: Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41467-019-13743-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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ATAD2 AAA+ ATPases are a family of histone chaperones that regulate nucleosome density and chromatin dynamics. Here, authors find that the fission yeast ATAD2 homolog Abo1 deposits histone H3–H4 onto DNA in an ATP-hydrolysis-dependent manner, and present the cryo-EM structure of an ATAD2 family ATPase to reveal the structural basis of nucleosome assembly by Abo1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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