Nature Communications (Nov 2017)

Structural basis of arrestin-3 activation and signaling

  • Qiuyan Chen,
  • Nicole A. Perry,
  • Sergey A. Vishnivetskiy,
  • Sandra Berndt,
  • Nathaniel C. Gilbert,
  • Ya Zhuo,
  • Prashant K. Singh,
  • Jonas Tholen,
  • Melanie D. Ohi,
  • Eugenia V. Gurevich,
  • Chad A. Brautigam,
  • Candice S. Klug,
  • Vsevolod V. Gurevich,
  • T. M. Iverson

DOI
https://doi.org/10.1038/s41467-017-01218-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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While arrestins are mainly associated with GPCR signaling, arrestin-3 can signal independently of receptor interaction. Here the authors present the structure of arrestin-3 bound to inositol hexakisphosphate (IP6) and propose a model for arrestin-3 activation.