Effects of simultaneous pancreas-kidney transplantation and kidney transplantation alone on the outcome of peripheral vascular diseases

Abstract

Abstract Background The effects of Simultaneous Pancreas Kidney Transplantation (SPKT) on Peripheral Vascular Disease (PVD) warrants additional study and more target focus, since little is known about the mid- and long-term effects on the progression of PVD after transplantation. Methods 101 SPKT and 26 Kidney Transplantation Alone (KTA) recipients with insulin-dependent diabetes mellitus (IDDM) were retrospectively evaluated with regard to graft and metabolic outcome. Special subgroup analysis was directed towards the development and progression of peripheral vascular complications (PVC) (amputation, ischemic ulceration, lower extremity angioplasty/ bypass surgery) after transplantation. Results The 10-year patient survival was significantly higher in the SPKT group (SPKT: 82% versus KTA 40%; P 8 years after transplantation. Conclusion SPKT favorably slows down development and progression of PVD by maintaining a superior metabolic vascular risk profile in patients with IDDM1.

Keywords

• Pancreas transplantation
• Kidney transplantation alone
• Diabetes mellitus
• Peripheral arterial disease
• Diabetic vasculopathy
• Vascular steal syndrome