Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity
Timothy R D J Radstake,
Joel A G van Roon,
Maarten R Hillen,
Sofie L M Blokland,
Aridaman Pandit,
Katia Urso,
Emma Koppe,
Ana Pinheiro Lopes,
Tom Slocombe,
André van Maurik
Affiliations
Timothy R D J Radstake
Center for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands
Joel A G van Roon
1 Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Maarten R Hillen
Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
Sofie L M Blokland
Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, UMC, Utrecht, The Netherlands
Aridaman Pandit
4 Dept of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands
Katia Urso
GSK Immunology Network and Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UK
Emma Koppe
GSK Immunology Network and Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UK
Ana Pinheiro Lopes
Centre for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
Tom Slocombe
GSK Immunology Network and Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UK