A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex

Yaqiong Chen; Jiang Wang; Yibing Wang; Pengfei Wang; Zan Zhou; Rong Wu; Qian Xu; Hanyun You; Yaxin Liu; Lei Wang; Lingqin Zhou; Yuting Wu; Lihong Hu; Hong Liu; Yi Liu

doi:10.1038/s41467-021-27533-9

Nature Communications (Jan 2022)

A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex

Yaqiong Chen,
Jiang Wang,
Yibing Wang,
Pengfei Wang,
Zan Zhou,
Rong Wu,
Qian Xu,
Hanyun You,
Yaxin Liu,
Lei Wang,
Lingqin Zhou,
Yuting Wu,
Lihong Hu,
Hong Liu,
Yi Liu

Affiliations

Yaqiong Chen: Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Jiang Wang: State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yibing Wang: State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Pengfei Wang: University of Chinese Academy of Sciences
Zan Zhou: University of Chinese Academy of Sciences
Rong Wu: University of Chinese Academy of Sciences
Qian Xu: Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University
Hanyun You: Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine
Yaxin Liu: Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Lei Wang: Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Lingqin Zhou: Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
Yuting Wu: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences
Lihong Hu: Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine
Hong Liu: State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yi Liu: Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University

DOI: https://doi.org/10.1038/s41467-021-27533-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Disruption of CREB/CRTC2, a key gluconeogenic transcriptional complex, has been shown to ameliorate insulin resistance in mice. Here, the authors show that the inhibitor artipllin C and the synthetic compound A57, which presents with higher inhibitory activity, improve insulin sensitivity in obese mice by inhibiting CREB-CRTC2 interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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