Genetic determinants of cellular addiction to DNA polymerase theta

Wanjuan Feng; Dennis A. Simpson; Juan Carvajal-Garcia; Brandon A. Price; Rashmi J. Kumar; Lisle E. Mose; Richard D. Wood; Naim Rashid; Jeremy E. Purvis; Joel S. Parker; Dale A. Ramsden; Gaorav P. Gupta

doi:10.1038/s41467-019-12234-1

Nature Communications (Sep 2019)

Genetic determinants of cellular addiction to DNA polymerase theta

Wanjuan Feng,
Dennis A. Simpson,
Juan Carvajal-Garcia,
Brandon A. Price,
Rashmi J. Kumar,
Lisle E. Mose,
Richard D. Wood,
Naim Rashid,
Jeremy E. Purvis,
Joel S. Parker,
Dale A. Ramsden,
Gaorav P. Gupta

Affiliations

Wanjuan Feng: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Dennis A. Simpson: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Juan Carvajal-Garcia: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Brandon A. Price: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Rashmi J. Kumar: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Lisle E. Mose: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Richard D. Wood: Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center
Naim Rashid: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jeremy E. Purvis: Department of Genetics, University of North Carolina at Chapel Hill
Joel S. Parker: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Dale A. Ramsden: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Gaorav P. Gupta: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-019-12234-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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