Anti-Food Allergic Compounds from <i>Penicillium griseofulvum</i> MCCC 3A00225, a Deep-Sea-Derived Fungus
Cui-Ping Xing,
Dan Chen,
Chun-Lan Xie,
Qingmei Liu,
Tian-Hua Zhong,
Zongze Shao,
Guangming Liu,
Lian-Zhong Luo,
Xian-Wen Yang
Affiliations
Cui-Ping Xing
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China
Dan Chen
Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China
Chun-Lan Xie
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China
Qingmei Liu
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China
Tian-Hua Zhong
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China
Zongze Shao
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China
Guangming Liu
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China
Lian-Zhong Luo
Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China
Xian-Wen Yang
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China
Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC50 value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.
