水通道蛋白4与卒中后认知障碍的关系研究进展 Progress of the Relationship between Aquaporin 4 and Post-Stroke Cognitive Impairment

Abstract

卒中后认知障碍是卒中的重要后遗症之一，从病理上可以分为血管性、退变性及混合性认知障碍。水通道蛋白4广泛分布于中枢神经系统，参与多种神经系统疾病和认知障碍的病理过程，但其参与卒中后认知障碍的具体机制目前尚未明确。本文综述水通道蛋白4通过参与调节神经炎症、突触可塑性以及β-淀粉样蛋白的积聚和清除过程在卒中后认知障碍中发挥的可能作用。 Abstract: Post-stroke cognitive impairment is one of the main sequelae of stroke, which can be divided into vascular, degenerative and mixed cognitive impairment. Aquaporin 4 is widely distributed in the central nervous system and is involved in the pathological process of cognitive impairment and multiple nervous system diseases. However, the specific mechanism of aquaporin 4 in post-stroke cognitive impairment is not clear. This article reviewed the possible important role of aquaporin 4 in post-stroke cognitive impairment by involvement in the regulation of neuroinflammation, synaptic plasticity, and the accumulation and clearance of β-amyloid.

Keywords

• 水通道蛋白4
• 卒中后认知障碍
• 炎症因子
• β-淀粉样蛋白
• aquaporin 4
• post-stroke cognitive impairment
• inflammatory factor
• β-amyloid