Roles and mechanisms of CircRNAs in ovarian cancer

Min Liu; Siyu Cao; Ziyi Guo; Zong Wu; Jiao Meng; Jiao Meng; Yong Wu; Yong Wu; Yang Shao; Yang Shao; Yanli Li

doi:10.3389/fcell.2022.1044897

Frontiers in Cell and Developmental Biology (Nov 2022)

Roles and mechanisms of CircRNAs in ovarian cancer

Min Liu,
Siyu Cao,
Ziyi Guo,
Zong Wu,
Jiao Meng,
Jiao Meng,
Yong Wu,
Yong Wu,
Yang Shao,
Yang Shao,
Yanli Li

Affiliations

Min Liu: Lab for Noncoding RNA and Cancer, School of Life Sciences, Shanghai University, Shanghai, China
Siyu Cao: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
Ziyi Guo: Lab for Noncoding RNA and Cancer, School of Life Sciences, Shanghai University, Shanghai, China
Zong Wu: Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jiao Meng: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China
Jiao Meng: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Yong Wu: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Yong Wu: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
Yang Shao: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China
Yang Shao: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Yanli Li: Lab for Noncoding RNA and Cancer, School of Life Sciences, Shanghai University, Shanghai, China

DOI: https://doi.org/10.3389/fcell.2022.1044897
Journal volume & issue: Vol. 10

Abstract

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Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that circRNAs have different biological function, including sponging miRNAs, encoding micropeptides, regulating stability of cytoplasmic mRNAs, affecting transcription and splicing, via interacting with DNA, RNA and proteins. Due to their stability, circRNAs have the potential of acting as biomarkers and treatment targets. In this review, we briefly illustrate the biogenesis mechanism and biological function of circRNAs in OC, and make a perspective of circRNAs drug targeting immune responses and signaling pathways in OC. This article can provide a systematic view into the current situation and future of circRNAs in OC.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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