Cell Growth Inhibition of Saponin XII from <i>Dipsacus japonicus</i> Miq. on Acute Myeloid Leukemia Cells

Ba Thi Cham; Nguyen Thi Thuy Linh; Do Thi Thao; Nguyen Thi Hoang Anh; Nguyen Thanh Tam; Bui Kim Anh; Isabella Muscari; Sabrina Adorisio; Tran Van Sung; Trinh Thi Thuy; Domenico V. Delfino

doi:10.3390/molecules25153325

Molecules (Jul 2020)

Cell Growth Inhibition of Saponin XII from <i>Dipsacus japonicus</i> Miq. on Acute Myeloid Leukemia Cells

Ba Thi Cham,
Nguyen Thi Thuy Linh,
Do Thi Thao,
Nguyen Thi Hoang Anh,
Nguyen Thanh Tam,
Bui Kim Anh,
Isabella Muscari,
Sabrina Adorisio,
Tran Van Sung,
Trinh Thi Thuy,
Domenico V. Delfino

Affiliations

Ba Thi Cham: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Nguyen Thi Thuy Linh: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Do Thi Thao: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Nguyen Thi Hoang Anh: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Nguyen Thanh Tam: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Bui Kim Anh: Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Isabella Muscari: Section of onco-hematology, Department of Medicine, University of Perugia, 06132 Perugia, Italy
Sabrina Adorisio: Foligno Nursing School, Department of Medicine, University of Perugia, 06132 Perugia, Italy
Tran Van Sung: Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Trinh Thi Thuy: Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi 100000, Vietnam
Domenico V. Delfino: Foligno Nursing School, Department of Medicine, University of Perugia, 06132 Perugia, Italy

DOI: https://doi.org/10.3390/molecules25153325
Journal volume & issue: Vol. 25, no. 15
p. 3325

Abstract

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In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G0/G1 phase of the cell cycle, with a decrease of cells in the S and G2/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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