PopTradeOff: A database for exploring population-specificity of adaptive evolution, disease susceptibility, and drug responsiveness

Abstract

The influence of adaptive evolution on disease susceptibility has drawn attention; however, the extent of the influence, whether favored mutations also influence drug responses, and whether the associations between the three are population-specific remain unknown. Using a reported deep learning network to integrate seven statistical tests for detecting selection signals, we predicted favored mutations in the genomes of 17 human populations and integrated these favored mutations with reported GWAS sites and drug response-related variants into the database PopTradeOff (http://www.gaemons.net/PopFMIntro). The database also contains genome annotation information on the SNP, sequence, gene, and pathway levels. The preliminary data analyses suggest that substantial associations exist between adaptive evolution, disease susceptibility, and drug responses and that the associations are highly population-specific. The database may be valuable for disease studies, drug development, and personalized medicine.

Keywords

• Database
• Favored mutation
• GWAS
• Disease susceptibility
• Drug responsiveness