A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Lin Wang; Jingzheng Li; Hu Zhou; Weidao Zhang; Jing Gao; Ping Zheng

doi:10.1038/s41467-021-25827-6

Nature Communications (Sep 2021)

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Lin Wang,
Jingzheng Li,
Hu Zhou,
Weidao Zhang,
Jing Gao,
Ping Zheng

Affiliations

Lin Wang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Jingzheng Li: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Hu Zhou: Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Weidao Zhang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Jing Gao: Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ping Zheng: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-25827-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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