Nature Communications (Apr 2019)
Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
- Polina Denichenko,
- Maxim Mogilevsky,
- Antoine Cléry,
- Thomas Welte,
- Jakob Biran,
- Odelia Shimshon,
- Georgina D. Barnabas,
- Miri Danan-Gotthold,
- Saran Kumar,
- Eylon Yavin,
- Erez Y. Levanon,
- Frédéric H. Allain,
- Tamar Geiger,
- Gil Levkowitz,
- Rotem Karni
Affiliations
- Polina Denichenko
- Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School
- Maxim Mogilevsky
- Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School
- Antoine Cléry
- Institute of Molecular Biology and Biophysics, ETH Zurich
- Thomas Welte
- Dynamic Biosensors, GmbH
- Jakob Biran
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Odelia Shimshon
- Department of Medicinal Chemistry, Institute for Drug Research, Hebrew University-Hadassah Medical School
- Georgina D. Barnabas
- Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University
- Miri Danan-Gotthold
- Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Saran Kumar
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University-Hadassah Medical School
- Eylon Yavin
- Department of Medicinal Chemistry, Institute for Drug Research, Hebrew University-Hadassah Medical School
- Erez Y. Levanon
- Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Frédéric H. Allain
- Institute of Molecular Biology and Biophysics, ETH Zurich
- Tamar Geiger
- Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University
- Gil Levkowitz
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Rotem Karni
- Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School
- DOI
- https://doi.org/10.1038/s41467-019-09523-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.
