Crystallization Selectivity of Ribavirin Solution and Amorphous Phase
Fuying Li,
Shiying Chen,
Haoxin Hu,
Chengfeng Liang,
Shiyu Sun,
Can Jin,
Fenghua Chen
Affiliations
Fuying Li
Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China
Shiying Chen
Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China
Haoxin Hu
College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China
Chengfeng Liang
Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China
Shiyu Sun
Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China
Can Jin
Torch High Technology Industry Development Center, Ministry of Science and Technology, Beijing 100045, China
Fenghua Chen
Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China
Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and DMSO solution are compared via mid-frequency Raman difference spectra (MFRDS). The crystallization process from amorphous ribavirin to Form I and from solution to amorphous phase is explained. Reasons for the difficulty in preparing the DMSO solvate are proposed. The rationale provided for the crystallization selectivity provides a foundation for the synthesis of metastable phases with a robust and convenient method.
