Association of genetic polymorphism of a gene TNF-α (G-308A) with formation of the serious and complicated forms of a influenza at children

Abstract

Research of prevalence of a polymorphic marker of a gene of the factor of a necrosis of tumors-α G-308A at 201 children is carried out at the uncomplicated and complicated current of influenza A H1N1pdm09. It is established, that frequency of prevalence of genotypes G/G and G/A at children with not serious forms of influenza A H1N1pdm09 and at a seasonal influenza corresponds population. In case of development of a pneumonia in children at influenza A H1N1pdm09, irrespective of gravity of its current, and also at a serious current of a bacterial pneumonia, distribution of genotypes G/G and G/A differed from healthy population of children. It is revealed, that an allele A polymorphism G-308A of a gene of the factor of a necrosis of tumors-α associations with development of the serious and complicated current of influenza A H1N1pdm09.

Keywords

• грипп
• пневмония
• дети
• полиморфизм
• цитокины