Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

Abstract

The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection, but remains virulent in a mouse model of systemic candidiasis.