Nature Communications (May 2016)

Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

  • Shin-ichiro Honda,
  • Kazuki Sato,
  • Naoya Totsuka,
  • Satoshi Fujiyama,
  • Manabu Fujimoto,
  • Kensuke Miyake,
  • Chigusa Nakahashi-Oda,
  • Satoko Tahara-Hanaoka,
  • Kazuko Shibuya,
  • Akira Shibuya

DOI
https://doi.org/10.1038/ncomms11498
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.