Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J

Lian-Dong Guo; Yan Zhang; Jingping Hu; Chengqing Ning; Heyifei Fu; Yuye Chen; Jing Xu

doi:10.1038/s41467-020-17350-x

Nature Communications (Jul 2020)

Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J

Lian-Dong Guo,
Yan Zhang,
Jingping Hu,
Chengqing Ning,
Heyifei Fu,
Yuye Chen,
Jing Xu

Affiliations

Lian-Dong Guo: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Yan Zhang: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Jingping Hu: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Chengqing Ning: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Heyifei Fu: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Yuye Chen: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Jing Xu: Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-17350-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 6

Abstract

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Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum alkaloid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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