INDICATORS OF CELLULAR AND HUMORAL IMMUNITY IN EXPERIMENTAL INFLAMMATION OF PERIODONTAL TISSUES

Abstract

The article addresses the estimation of parameters of cellular and humoral immunity 130 white Wistar rats with experimentally reproduced by inflammation of periodontal tissues. The animals were experimentally simulated gingivitis, periodontitis, periodontal disease. Evaluation of the immune status of the rats showed that all parts of immunity change in varying degrees. The development of experimental inflammation of the periodontal tissues against the backdrop of changes in both cellular and humoral General immune status, is to reduce the content of total Mature T-lymphocytes (CD3+) and T-lymphocytes-helper cells (CD4+); increase of T-suppressors (CD8+) and decrease of the relative content of b-lymphocytes (CD20+). The use of glucosamine hydrochloride and chondroitin sulfate helps to normalize the cytokine profile leads to the relief of local inflammatory process, arising on a background of cytokine imbalance.

Keywords

• иммунитет
• воспаление
• эксперимент
• пародонт
• immunity
• inflammation
• experiment
• periodontal