Prognostic factors of chronic pulmonary aspergillosis: A retrospective cohort of 264 patients from Japan.

Abstract

BackgroundChronic pulmonary aspergillosis (CPA) develops in various underlying pulmonary conditions. There is scarce data evaluating interstitial lung disease (ILD)/abnormalities (ILA) as such conditions, and it has not been explored much whether non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a prognostic factor for mortality in CPA patients. Few reports had investigated prognostic factors of CPA including underlying pulmonary conditions.ObjectivesTo explore prognostic factors of CPA including pulmonary conditions.MethodsWe conducted a retrospective cohort study of 264 CPA patients from a center for pulmonary aspergillosis in Japan.ResultsSurvival rates were 78.7%, 61.0%, and 47.4% at 1, 3, and 5 years, respectively. Of 264 patients, 53 (20.1%) and 87 (33.1%) were complicated with ILA and NTM-PD. Several independent prognostic factors were identified by multivariate Cox proportional analysis: ILA (HR 1.76, 95%CI 1.06-2.92, p = 0.029), age (1.05, 1.02-1.08, pConclusionsThe poor prognosis of CPA and several prognostic factors were revealed. Early diagnosis and intervention is required with reference to such factors.