Nature Communications (Jan 2020)
Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium
- Ingrid Gomez,
- Ben Ward,
- Celine Souilhol,
- Chiara Recarti,
- Mark Ariaans,
- Jessica Johnston,
- Amanda Burnett,
- Marwa Mahmoud,
- Le Anh Luong,
- Laura West,
- Merete Long,
- Sion Parry,
- Rachel Woods,
- Carl Hulston,
- Birke Benedikter,
- Chiara Niespolo,
- Rohit Bazaz,
- Sheila Francis,
- Endre Kiss-Toth,
- Marc van Zandvoort,
- Andreas Schober,
- Paul Hellewell,
- Paul C. Evans,
- Victoria Ridger
Affiliations
- Ingrid Gomez
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Ben Ward
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Celine Souilhol
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Chiara Recarti
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Mark Ariaans
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Jessica Johnston
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Amanda Burnett
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Marwa Mahmoud
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Le Anh Luong
- William Harvey Research Institute, Queen Mary University
- Laura West
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Merete Long
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Sion Parry
- School of Sport, Exercise and Health Sciences, Loughborough University
- Rachel Woods
- School of Sport, Exercise and Health Sciences, Loughborough University
- Carl Hulston
- School of Sport, Exercise and Health Sciences, Loughborough University
- Birke Benedikter
- Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Chiara Niespolo
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Rohit Bazaz
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Sheila Francis
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Endre Kiss-Toth
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Marc van Zandvoort
- Department of Molecular Cell Biology, CARIM School for Cardiovascular Diseases, Maastricht University
- Andreas Schober
- Experimental Vascular Medicine, Ludwig-Maximilian University of Munich
- Paul Hellewell
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Paul C. Evans
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- Victoria Ridger
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield
- DOI
- https://doi.org/10.1038/s41467-019-14043-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
The role of neutrophils in the development of atherosclerosis has long been an enigma, with few neutrophils detected within the plaque. Here, the authors show that microvesicles released from neutrophils increase vascular inflammation and enhance atherosclerotic plaque formation through delivery of miR-155.
