A rare case of frontotemporal dementia with amyotrophic lateral sclerosis

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by progressive degeneration of the frontal and temporal lobes which typically presents with cognitive symptoms. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive degeneration of upper and lower motor neurons, leading to symptoms of motor weakness. We present a case of behavioral variant of FTD with ALS. The patient presented with changes in his behavior followed by impaired memory and progressive weakness of bilateral upper limbs. Patient eventually developed difficulty swallowing and recognizing faces too. The case highlights the association between FTD and ALS.

Keywords

• amyotrophic lateral sclerosis
• frontotemporal dementia
• tauopathies
• tdp-43 proteinopathies