Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning

Guhuan Liu; Jiajia Tan; Jie Cen; Guoying Zhang; Jinming Hu; Shiyong Liu

doi:10.1038/s41467-022-28227-6

Nature Communications (Jan 2022)

Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning

Guhuan Liu,
Jiajia Tan,
Jie Cen,
Guoying Zhang,
Jinming Hu,
Shiyong Liu

Affiliations

Guhuan Liu: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China
Jiajia Tan: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China
Jie Cen: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China
Guoying Zhang: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China
Jinming Hu: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China
Shiyong Liu: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-022-28227-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Permselectivity of cellular membranes is crucial to normal cellular function but this has been hard to replicate in artificial cells. Here, the authors use pH-responsive polymersomes containing Schiff base moieties which can be used to control mesh size allowing for selective permeability control creating responsive systems.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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