The effect of swimming exercise on the expression of CYP17A1 and CYP19A1 genes in ovary tissue of healthy Wistar rats

Abstract

Background and aims: CYP17A1 and CYP19A2 enzymes are key proteins in constructing and regulating steroid hormones such as cortisol, testosterone and estrogen. But the effect of exercise on these two proteins in ovary tissue has not been investigated yet. The purpose of present study was investigating the effect of swimming training on CYP17A1 and CYP19A1 gene expression in ovary tissue of healthy Wistar rats. Method: 20 two months healthy Wistar rats, mean weight of 180±20 gr were selected and divided to two groups of exercise (n=10) and control (n=10) randomly. Exercise group performed swimming five days in a week for 6 weeks. Statistical test of Mann-Whitney was used for data analysis. Results: CYP17A1 and CYP19 gene expression increased significantly in exercise compared to control group (P=0.05). Conclusion: regarding the role of CYP17 and CYP19 in steroid hormone synthesis, probably six weeks of swimming can be an important non pharmacological intervention for treatment of ovulation and infertility problems.

Keywords

• cyp17a1
• cyp19a1
• swimming training
• ovary tissue