Nature Communications (Aug 2020)
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles
Abstract
The investigation of reactivity of β,γ-unsaturated carbonyl compounds is of great synthetic value, especially in asymmetric transformations. Here, the authors report a catalytic asymmetric tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in presence of chiral N,N′-dioxide metal catalysts.