Nature Communications (Aug 2020)

Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles

  • Tengfei Kang,
  • Liuzhen Hou,
  • Sai Ruan,
  • Weidi Cao,
  • Xiaohua Liu,
  • Xiaoming Feng

DOI
https://doi.org/10.1038/s41467-020-17681-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

The investigation of reactivity of β,γ-unsaturated carbonyl compounds is of great synthetic value, especially in asymmetric transformations. Here, the authors report a catalytic asymmetric tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in presence of chiral N,N′-dioxide metal catalysts.