Serum biochemical parameters of patients with periprothetic joint infection of the hip in carbohydrate metabolism disorders

Abstract

Introduction As the demand for joint replacement increases over time, the number of concurrent complications such as periprosthetic joint infection (PJI) will also increase. Surgical approaches in carbohydrate metabolism disorders (CMD) remain under-explored. Epidemiological and pathogenetic aspects of the metabolic status of patients with PJI and disorders of carbohydrate metabolism must be examined prior to revision total hip replacement. The objective was to identify statistically significant differences in blood serum biochemical parameters in patients with PJI of the hip joint in groups of patients with and without carbohydrate metabolism disorders. Material and methods The blood serum of 76 patients with PJI of the hip without a history of carbohydrate metabolism disorders and 56 patients with PJI of the hip and CMD as a concomitant pathology was examined. Patients had a history of diabetes mellitus and impaired glucose tolerance. Obesity, a preclinical form of CMD, was determined by calculating the body mass index (BMI > 30). Serum C-reactive protein (CRP), bilirubin, glucose, urea, total protein, albumin and globulins, creatinine, aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured using an automatic biochemical analyzer ILab Aries and BioSystems reagent kits. The measurements were compared using generally accepted methods of variation statistics. Results C-reactive protein and globulin levels were increased (the albumin-globulin coefficient was not within normal limits) in patients with PJI. Fasting glycemia, urea and creatinine showed significant differences in patients with CMD as compared comparison with those in no-CMD patients. Reliable excesses of the measurements do not, however, deduce them beyond the limits of normal values. Discussion Our findings indicate preclinical renal changes in patients with PJI of the hip and CMD.

Keywords

• periprosthetic joint infection
• diabetes mellitus
• impaired glucose tolerance
• body mass index
• creatinine
• urea