Scientific Reports (Jun 2024)
Hodgkin lymphoma: hypodense lesions in mediastinal masses
- Adrian Damek,
- Lars Kurch,
- Friedrich Christian Franke,
- Andishe Attarbaschi,
- Auke Beishuizen,
- Michaela Cepelova,
- Francesco Ceppi,
- Stephen Daw,
- Karin Dieckmann,
- Ana Fernández-Teijeiro,
- Tobias Feuchtinger,
- Jamie E. Flerlage,
- Alexander Fosså,
- Thomas W. Georgi,
- Dirk Hasenclever,
- Andrea Hraskova,
- Jonas Karlen,
- Tomasz Klekawka,
- Regine Kluge,
- Dieter Körholz,
- Judith Landman-Parker,
- Thierry Leblanc,
- Christine Mauz-Körholz,
- Markus Metzler,
- Jane Pears,
- Jonas Steglich,
- Anne Uyttebroeck,
- Dirk Vordermark,
- William Hamish Wallace,
- Walter Alexander Wohlgemuth,
- Dietrich Stoevesandt
Affiliations
- Adrian Damek
- Department of Radiology, University Hospital Halle/Saale
- Lars Kurch
- Department of Nuclear Medicine, University of Leipzig
- Friedrich Christian Franke
- Department of Radiology, University Hospital Halle/Saale
- Andishe Attarbaschi
- Department of Pediatric Hematology and Oncology, St. Anna Children’s Hospital, Medical University of Vienna
- Auke Beishuizen
- Erasmus MC-Sophia Children’s Hospital
- Michaela Cepelova
- Department of Pediatric Hematology and Oncology, University Hospital Motol and Second Medical Faculty of Charles University
- Francesco Ceppi
- Division of Pediatrics, Department of Woman-Mother-Child, Pediatric Hematology-Oncology Unit, University Hospital of Lausanne
- Stephen Daw
- Department of Pediatric Hematology and Oncology, University College London Hospitals
- Karin Dieckmann
- Department of Radiation Oncology, University Hospital Vienna
- Ana Fernández-Teijeiro
- Pediatric Onco-Hematology Unit, Hospital Universitario Virgen Macarena
- Tobias Feuchtinger
- Pediatric Hematology, Oncology and Stem Cell Transplantation, Dr. Von Hauner University Children’s Hospital Ludwig-Maximilians-University
- Jamie E. Flerlage
- Department of Oncology, St. Jude Children’s Research Hospital
- Alexander Fosså
- Department of Medical Oncology and Radiotherapy, Oslo University Hospital
- Thomas W. Georgi
- Department of Nuclear Medicine, University of Leipzig
- Dirk Hasenclever
- Institute of Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig
- Andrea Hraskova
- Department of Pediatric Hematology and Oncology, University Children’s Hospital
- Jonas Karlen
- Karolinska University Hospital, Astrid Lindgrens Childrens Hospital
- Tomasz Klekawka
- Institute of Pediatrics, Jagiellonian University Medical College
- Regine Kluge
- Department of Nuclear Medicine, University of Leipzig
- Dieter Körholz
- Department of Pediatric Hematology and Oncology, Justus-Liebig University
- Judith Landman-Parker
- Hôpital Armand-Trousseau Sorbonne Universitè
- Thierry Leblanc
- Service d’Hématologie Pédiatrique, Hôpital Robert-Debré
- Christine Mauz-Körholz
- Department of Pediatric Hematology and Oncology, Justus-Liebig University
- Markus Metzler
- Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine, University Hospital
- Jane Pears
- Department of Pediatric Hematology and Oncology, Our Lady’s Children’s Hospital
- Jonas Steglich
- Department of Radiology, University Hospital Halle/Saale
- Anne Uyttebroeck
- Department of Pediatric Hematology and Oncology, University Hospitals Leuven
- Dirk Vordermark
- Department of Radiation Oncology, Medical Faculty of the Martin-Luther-University
- William Hamish Wallace
- Department of Paediatric Oncology, Royal Hospital for Sick Children, University of Edinburgh
- Walter Alexander Wohlgemuth
- Department of Radiology, University Hospital Halle/Saale
- Dietrich Stoevesandt
- Department of Radiology, University Hospital Halle/Saale
- DOI
- https://doi.org/10.1038/s41598-024-64253-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 9
Abstract
Abstract Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.
Keywords
