Nature Communications (Jan 2018)
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway
- Irene Santos-Barriopedro,
- Laia Bosch-Presegué,
- Anna Marazuela-Duque,
- Carolina de la Torre,
- Carlota Colomer,
- Berta N. Vazquez,
- Thomas Fuhrmann,
- Bárbara Martínez-Pastor,
- Wenfu Lu,
- Thomas Braun,
- Eva Bober,
- Thomas Jenuwein,
- Lourdes Serrano,
- Manel Esteller,
- Zhenbang Chen,
- Silvia Barceló-Batllori,
- Raúl Mostoslavsky,
- Lluis Espinosa,
- Alejandro Vaquero
Affiliations
- Irene Santos-Barriopedro
- Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- Laia Bosch-Presegué
- Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- Anna Marazuela-Duque
- Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- Carolina de la Torre
- Proteomics Unit, Bellvitge Biomedical Research Institute (IDIBELL)
- Carlota Colomer
- Program in Cancer Research, IMIM-Hospital del Mar, Barcelona Biomedical Research Park (PRBB)
- Berta N. Vazquez
- Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey
- Thomas Fuhrmann
- Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51
- Bárbara Martínez-Pastor
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Wenfu Lu
- Department of Biochemistry and Cancer Biology, Meharry Medical College
- Thomas Braun
- Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research
- Eva Bober
- Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research
- Thomas Jenuwein
- Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51
- Lourdes Serrano
- Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey
- Manel Esteller
- Cancer Epigenetics Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- Zhenbang Chen
- Department of Biochemistry and Cancer Biology, Meharry Medical College
- Silvia Barceló-Batllori
- Proteomics Unit, Bellvitge Biomedical Research Institute (IDIBELL)
- Raúl Mostoslavsky
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Lluis Espinosa
- Program in Cancer Research, IMIM-Hospital del Mar, Barcelona Biomedical Research Park (PRBB)
- Alejandro Vaquero
- Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- DOI
- https://doi.org/10.1038/s41467-017-02586-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB pathway.
