NATURAL HISTORY OF RALD: A 20 YEAR FOLLOW-UP OF A NRAS MUTATED PATIENT EXCLUDING A MALIGNANT PROGRESSION

• Enrico Attardi,
• Beatrice Rivalta,
• Cristina Cifaldi,
• Vittorio Rosti,
• Lucia Pacillo,
• Hajro Hajrullaj,
• Silvia Di Cesare,
• Matteo Luciani,
• Federica Barzaghi,
• Andrea Finocchi,
• Gigliola Di Matteo,
• Alessandro Aiuti,
• Franco Locatelli,
• Maria Teresa Voso,
• Giuseppe Palumbo,
• Caterina Cancrini

Affiliations

Enrico Attardi

PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy;; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

Beatrice Rivalta

PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy;; Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;

Cristina Cifaldi

Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;

Vittorio Rosti

Center for the Study of Myelofibrosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy;

Lucia Pacillo

PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy;; Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;

Hajro Hajrullaj

PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy;; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

Silvia Di Cesare

Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;

Matteo Luciani

Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;

Federica Barzaghi

Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;

Andrea Finocchi

Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;

Gigliola Di Matteo

Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;

Alessandro Aiuti

Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy;

Franco Locatelli

Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy

Maria Teresa Voso

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

Giuseppe Palumbo

Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;

Caterina Cancrini

Academic department of Pediatrics, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy;; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;