Hemorheology and hemostasis in ischemic stroke patients treated with i.v. thrombolysis

Abstract

Hemostatic and hemorheological dysregulations are the typicalpathological conditions in stroke. Thorough dynamic examinationsof hemostasis, platelet aggregation, kinetics of erythrocyteaggregation/disaggregation along with clinical and neuroimagingfeatures and functional outcome were conducted in ischemicstroke patients who underwent i.v. thrombolysis or did not receivedrtPA. Increased strength of erythrocyte aggregates (SEA)was associated with better functional outcome, and that correlationwas stronger in patients treated with i.v. thrombolysis. Increased SEA was also associated with regression of ischemiclesion on DWI-MRI on Day 3 day in patients treated with i.v.thrombolysis.

Keywords

• hemostasis
• hemorheology
• ischemic stroke
• i.v. thrombolysis
• erythrocyte aggregation