Nature Communications (May 2021)
Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
- Eckhard Schlemm,
- Thies Ingwersen,
- Alina Königsberg,
- Florent Boutitie,
- Martin Ebinger,
- Matthias Endres,
- Jochen B. Fiebach,
- Jens Fiehler,
- Ivana Galinovic,
- Robin Lemmens,
- Keith W. Muir,
- Norbert Nighoghossian,
- Salvador Pedraza,
- Josep Puig,
- Claus Z. Simonsen,
- Vincent Thijs,
- Anke Wouters,
- Christian Gerloff,
- Götz Thomalla,
- Bastian Cheng
Affiliations
- Eckhard Schlemm
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- Thies Ingwersen
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- Alina Königsberg
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- Florent Boutitie
- Hospices Civils de Lyon, Service de Biostatistique
- Martin Ebinger
- Centrum für Schlaganfallforschung Berlin (CSB), Charité - Universitätsmedizin Berlin, Campus Mitte
- Matthias Endres
- Centrum für Schlaganfallforschung Berlin (CSB), Charité - Universitätsmedizin Berlin, Campus Mitte
- Jochen B. Fiebach
- Centrum für Schlaganfallforschung Berlin (CSB), Charité - Universitätsmedizin Berlin, Campus Mitte
- Jens Fiehler
- Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf
- Ivana Galinovic
- Centrum für Schlaganfallforschung Berlin (CSB), Charité - Universitätsmedizin Berlin, Campus Mitte
- Robin Lemmens
- Department of Neurology, University Hospitals Leuven
- Keith W. Muir
- Institute of Neuroscience & Psychology, University of Glasgow
- Norbert Nighoghossian
- Department of Stroke Medicine, Université Claude Bernard Lyon 1, CREATIS CNRS UMR 5220-INSERM U1206
- Salvador Pedraza
- Department of Radiology, Institut de Diagnostic per la Image (IDI), Hospital Dr Josep Trueta, Institut d’Investigació Biomèdica de Girona (IDIBGI)
- Josep Puig
- Department of Radiology, Institut de Diagnostic per la Image (IDI), Hospital Dr Josep Trueta, Institut d’Investigació Biomèdica de Girona (IDIBGI)
- Claus Z. Simonsen
- Department of Neurology, Aarhus University Hospital
- Vincent Thijs
- Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne
- Anke Wouters
- Department of Neurology, University Hospitals Leuven
- Christian Gerloff
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- Götz Thomalla
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- Bastian Cheng
- Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-021-22786-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.
