In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium
Diana M. Vranceanu,
Elena Ungureanu,
Ionut C. Ionescu,
Anca C. Parau,
Vasile Pruna,
Irina Titorencu,
Mihaela Badea,
Cristina-Ștefania Gălbău,
Mihaela Idomir,
Mihaela Dinu,
Alina Vladescu (Dragomir),
Cosmin M. Cotrut
Affiliations
Diana M. Vranceanu
Faculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Elena Ungureanu
Faculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Ionut C. Ionescu
Faculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Anca C. Parau
National Institute of Research and Development for Optoelectronics INOE2000, 409 Atomistilor, 077125 Magurele, Romania
Vasile Pruna
Romanian Academy Institute of Cellular Biology and Pathology “Nicolae Simionescu”, 8 B.P. Hasdeu, 050568 Bucharest, Romania
Irina Titorencu
Romanian Academy Institute of Cellular Biology and Pathology “Nicolae Simionescu”, 8 B.P. Hasdeu, 050568 Bucharest, Romania
Mihaela Badea
Prophylactic and Clinical Disciplines, Department of Fundamental, Faculty of Medicine, Transilvania University of Brasov, 56 Nicolae Balcescu, 500019 Brasov, Romania
Cristina-Ștefania Gălbău
Prophylactic and Clinical Disciplines, Department of Fundamental, Faculty of Medicine, Transilvania University of Brasov, 56 Nicolae Balcescu, 500019 Brasov, Romania
Mihaela Idomir
Prophylactic and Clinical Disciplines, Department of Fundamental, Faculty of Medicine, Transilvania University of Brasov, 56 Nicolae Balcescu, 500019 Brasov, Romania
Mihaela Dinu
National Institute of Research and Development for Optoelectronics INOE2000, 409 Atomistilor, 077125 Magurele, Romania
Alina Vladescu (Dragomir)
National Institute of Research and Development for Optoelectronics INOE2000, 409 Atomistilor, 077125 Magurele, Romania
Cosmin M. Cotrut
Faculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Biomaterials are an important and integrated part of modern medicine, and their development and improvement are essential. The fundamental requirement of a biomaterial is found to be in its interaction with the surrounding environment, with which it must coexist. The aim of this study was to assess the biological characteristics of hydroxyapatite (HAp)-based coatings doped with Mg and Zn ions obtained by the pulsed galvanostatic electrochemical method on the surface of pure titanium (cp-Ti) functionalized with titanium dioxide nanotubes (NTs TiO2) obtained by anodic oxidation. The obtained results highlighted that the addition of Zn or Mg into the HAp structure enhances the in vitro response of the cp-Ti surface functionalized with NT TiO2. The contact angle and surface free energy showed that all the developed surfaces have a hydrophilic character in comparison with the cp-Ti surface. The HAp-based coatings doped with Zn registered superior values than the ones with Mg, in terms of biomineralization, electrochemical behavior, and cell interaction. Overall, it can be said that the addition of Mg or Zn can enhance the in vitro behavior of the HAp-based coatings in accordance with clinical requirements. Antibacterial tests showed that the proposed HAp-Mg coatings had no efficiency against Escherichia coli, while the HAp-Zn coatings registered the highest antibacterial efficiency.
