Armaghane Danesh Bimonthly Journal (Sep 2013)
The effective impacts of Angi- Pars on Expression of Some CXC Chemokines Group in STZ-Induced Diabetic Rats
Abstract
Abstract Background & aim: Diabetes mellitus (DM) has destructive tissue effects via inducing oxidative stress. The aim of this study was to evaluate the Angi Pars effects on the expression of some CXC group of streptozotocin-induced diabetic rats. Methods: This experimental study was conducted on 48 male rats. Induced diabetic rats were done by 50 mg/ kg of Streptozotocin. 56 days after induction of diabetes, rats were randomly divided into 4 groups including control, untreated diabetic, insulin-treated diabetic and diabetic treated with insulin and Angipars. 24 h after the last injection the animals were bled and the expression of cxc Chemokines groups were measured by western blotting. Data were analyzed by t test. Results: Showed that CXCL10 was reduced in the treatment group and the treatment group receiving insulin in combination with angi - pars decreased significantly (P<0.05). The total concentration of CXCL12 chemokine showed that the concentration of the different groups did not change compared to the control group (P<0.05). The study showed that CXCL1 levels in the group receiving insulin in combination with angi-pars the chemokine concentration was significantly lower than the control group (P<0.05). Conclusion: Since, Angi-Pars consists of two major phenolic compound groups, 7 - hydroxy coumarin and flavonoids, has antioxidant, and controls the inflammatory effects of chemokine increase and balances between chemokines its effectiveness in angiogenesis can be maintain. Key words: Diabetes, Angi- Pars, Chemokines
