Nature Communications (Feb 2020)
The role of Mediator and Little Elongation Complex in transcription termination
- Hidehisa Takahashi,
- Amol Ranjan,
- Shiyuan Chen,
- Hidefumi Suzuki,
- Mio Shibata,
- Tomonori Hirose,
- Hiroko Hirose,
- Kazunori Sasaki,
- Ryota Abe,
- Kai Chen,
- Yanfeng He,
- Ying Zhang,
- Ichigaku Takigawa,
- Tadasuke Tsukiyama,
- Masashi Watanabe,
- Satoshi Fujii,
- Midori Iida,
- Junichi Yamamoto,
- Yuki Yamaguchi,
- Yutaka Suzuki,
- Masaki Matsumoto,
- Keiichi I. Nakayama,
- Michael P. Washburn,
- Anita Saraf,
- Laurence Florens,
- Shigeo Sato,
- Chieri Tomomori-Sato,
- Ronald C. Conaway,
- Joan W. Conaway,
- Shigetsugu Hatakeyama
Affiliations
- Hidehisa Takahashi
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Amol Ranjan
- Stowers Institute for Medical Research
- Shiyuan Chen
- Stowers Institute for Medical Research
- Hidefumi Suzuki
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Mio Shibata
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Tomonori Hirose
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Hiroko Hirose
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Kazunori Sasaki
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Ryota Abe
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Kai Chen
- Stowers Institute for Medical Research
- Yanfeng He
- Stowers Institute for Medical Research
- Ying Zhang
- Stowers Institute for Medical Research
- Ichigaku Takigawa
- Graduate School of Information Science and Technology, Hokkaido University
- Tadasuke Tsukiyama
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Masashi Watanabe
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Satoshi Fujii
- Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
- Midori Iida
- Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
- Junichi Yamamoto
- Department of Nanoparticle Translational Research Tokyo Medical University
- Yuki Yamaguchi
- Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
- Yutaka Suzuki
- Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Masaki Matsumoto
- Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
- Keiichi I. Nakayama
- Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
- Michael P. Washburn
- Stowers Institute for Medical Research
- Anita Saraf
- Stowers Institute for Medical Research
- Laurence Florens
- Stowers Institute for Medical Research
- Shigeo Sato
- Stowers Institute for Medical Research
- Chieri Tomomori-Sato
- Stowers Institute for Medical Research
- Ronald C. Conaway
- Stowers Institute for Medical Research
- Joan W. Conaway
- Stowers Institute for Medical Research
- Shigetsugu Hatakeyama
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- DOI
- https://doi.org/10.1038/s41467-020-14849-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies.
