Nature Communications (Apr 2022)
TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease
- Renee E. Vickman,
- LaTayia Aaron-Brooks,
- Renyuan Zhang,
- Nadia A. Lanman,
- Brittany Lapin,
- Victoria Gil,
- Max Greenberg,
- Takeshi Sasaki,
- Gregory M. Cresswell,
- Meaghan M. Broman,
- J. Sebastian Paez,
- Jacqueline Petkewicz,
- Pooja Talaty,
- Brian T. Helfand,
- Alexander P. Glaser,
- Chi-Hsiung Wang,
- Omar E. Franco,
- Timothy L. Ratliff,
- Kent L. Nastiuk,
- Susan E. Crawford,
- Simon W. Hayward
Affiliations
- Renee E. Vickman
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- LaTayia Aaron-Brooks
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Renyuan Zhang
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Nadia A. Lanman
- Department of Comparative Pathobiology, Purdue University
- Brittany Lapin
- Biostatistics and Research Informatics, NorthShore University HealthSystem
- Victoria Gil
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Max Greenberg
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Takeshi Sasaki
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Gregory M. Cresswell
- Department of Comparative Pathobiology, Purdue University
- Meaghan M. Broman
- Department of Comparative Pathobiology, Purdue University
- J. Sebastian Paez
- Purdue Center for Cancer Research, Purdue University
- Jacqueline Petkewicz
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Pooja Talaty
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Brian T. Helfand
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Alexander P. Glaser
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Chi-Hsiung Wang
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Omar E. Franco
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Timothy L. Ratliff
- Department of Comparative Pathobiology, Purdue University
- Kent L. Nastiuk
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Susan E. Crawford
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- Simon W. Hayward
- Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29719-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Reduction of systemic autoimmunity using TNF blockers may also reduce inflammatory diseases in other organs. Here, the authors use a patient database and scRNA-seq to link autoimmune diseases to benign prostatic hyperplasia (BPH), and demonstrate that prostatic hyperplasia is reduced by TNF blockers in humans and mice.
