A novel variant of Chlamydia psittaci causing human psittacosis in China

Xincheng Qin; Jinwei Huang; Junrong Liang; Enhui Gong; Wen Wang; Yuankai Lv; Ling Hou; Jingdong Song; Yamin Sun; Bohai Wen; Jianguo Xu; Tian Qin

International Journal of Infectious Diseases (Oct 2024)

A novel variant of Chlamydia psittaci causing human psittacosis in China

Xincheng Qin,
Jinwei Huang,
Junrong Liang,
Enhui Gong,
Wen Wang,
Yuankai Lv,
Ling Hou,
Jingdong Song,
Yamin Sun,
Bohai Wen,
Jianguo Xu,
Tian Qin

Affiliations

Xincheng Qin: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Jinwei Huang: Department of Respiratory and Critical Care Medicine, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
Junrong Liang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Enhui Gong: Department of Respiratory and Critical Care Medicine, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
Wen Wang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Yuankai Lv: Department of Respiratory and Critical Care Medicine, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
Ling Hou: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Jingdong Song: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Yamin Sun: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Research Institute of Public Health, Nankai University, Tianjin, China
Bohai Wen: Beijing Institute of Microbiology and Epidemiology, Beijing, China
Jianguo Xu: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Tian Qin: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Corresponding author.

Journal volume & issue: Vol. 147
p. 107180

Abstract

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From January 2022 to November 2022, sporadic psittacosis occurred in Lishui city, China. The patients were presented with fever, cough, and pulmonary infiltration. Their clinical symptoms were not relieved after receiving cephalosporin, penicillin, beta-lactamase inhibitors, and quinolones. Metagenomic next-generation sequencing of bronchoalveolar lavage fluid samples from the patients revealed Chlamydia psittaci infection. Then, three C. psittaci strains were isolated from the patients. Their whole genome sequences (WGSs) were obtained, and a core genome multilocus sequence typing (cgMLST) method was developed to study the population structure of C. psittaci. Using the constructed cgMLST method, 72 WGSs were divided into four related groups and ten sub-clusters. The Lishui strains formed a unique population of C. psittaci, which might represent a new variant of C. psittaci. In vitro antimicrobial susceptibility testing suggested that the Lishui strains were sensitive to tetracycline, macrolides, quinolones, and no drug-resistance was observed.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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