Molecules
(Oct 2023)
Diastereoselective Cascade Cyclization of Diazoimides with Alkylidene Pyrazolones for Preparation of Pyrazole-Fused Oxa-Bridged Oxazocines
Kuo Wang,
Yue Zhang,
Lu-Yu Cai,
Xiu-Qing Song,
Chen Wang,
Jia-Rui Zhang,
Yi-Fan Pan,
Hong-Wu Zhao
Affiliations
Kuo Wang
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Yue Zhang
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Lu-Yu Cai
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Xiu-Qing Song
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Chen Wang
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Jia-Rui Zhang
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Yi-Fan Pan
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Hong-Wu Zhao
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
DOI
https://doi.org/10.3390/molecules28207021
Journal volume & issue
Vol. 28,
no. 20
Abstract
Read online
Under the catalysis of Rh2(OAc)4 (10 mol%) and binapbisphosphine ligand (±)-L3 (20 mol%) in DCE at 80 °C, the cascade cyclization of diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-fused oxa-bridged oxazocines in reasonable chemical yields. The chemical structure and relative configuration of title products were firmly identified by X-ray diffraction analysis.
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