Communications Biology (Jul 2022)

DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies

  • George Procopiou,
  • Paul J. M. Jackson,
  • Daniella di Mascio,
  • Jennifer L. Auer,
  • Chris Pepper,
  • Khondaker Miraz Rahman,
  • Keith R. Fox,
  • David E. Thurston

DOI
https://doi.org/10.1038/s42003-022-03633-0
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.